Matt Chapman homered twice, doubled and drove in five runs for the San Francisco Giants, who jumped on Joe Musgrove early in an 8-3 victory over the San Diego Padres on Friday night. Kyle Harrison (1-0), a 22-year-old lefty, got plenty of run support to overcome impressive home runs by Manny Machado and Fernando Tatis Jr. Tatis homered again off reliever Tyler Rogers. It was the first victory with the Giants for Bob Melvin, who left the Padres after two seasons to take over his hometown team amid reports of an irreparable relationship with San Diego general manager A.J. Preller.