Mike Yastrzemski homered and drove in two runs for the San Francisco Giants, who beat the sloppy, listless San Diego Padres 7-2 on Thursday night to open a one-game lead over Arizona for the NL's third wild-card spot. The Giants were up 7-0 before the Padres got their first hit, a single by Matthew Batten with two outs in the fifth off former Padres pitcher Sean Manaea (5-5).